— Predictive Enrollment Engineering™ —

Ryan Helber

Chief Strategy Officer · CT Scan

Patent-Pending · Predictive Enrollment Engineering
Enrollment
engineered
before
launch.

Two decades inside clinical research sites taught Ryan one truth: enrollment failures are planning failures. Today he leads strategy at CT Scan, building the forecast layer the industry has been missing.

Ryan Helber, Chief Strategy Officer at CT Scan
R.HelberCSO · 2026—
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§ 01 — About

The pattern behind every missed timeline.

For most of my career I've worked alongside research sites, coordinators, investigators, and leadership — helping studies open faster, run smoother, and stay financially sustainable.

Over time I noticed a pattern. Some studies are difficult no matter how strong the site is. Amazing teams still struggle. Timelines slip. The issue usually isn't effort. It's expectations.

Enrollment challenges begin long before activation. Projections are built on optimistic feasibility, incomplete referral assumptions, and historical comparisons that don't match the real patient pathway.

My work now focuses on helping the industry think about enrollment earlier — treating it as something that can be analyzed, forecasted, and engineered, instead of reacted to.

The Goal

better expectations → healthier sites → faster trials → more patients receiving therapies

§ 02 — Current Role
Chief Strategy Officer

CT Scan

Predictive Enrollment Engineering™ · powered by DYNO Ai™

CT Scan models the precise cost per enrollment for digital advertising — so sponsors know exactly how much must be spent to enroll a patient. Our proprietary engine, DYNO Ai™, transforms each protocol into a fully modeled enrollment blueprint with mathematical precision.

01

Cost-per-Enrollment Modeling

CT Scan mathematically models the digital advertising cost required to enroll a single patient — so sponsors know exactly what must be spent before a dollar is committed.

02

DYNO Ai™ Blueprint

DYNO Ai™ converts each protocol into a fully modeled enrollment blueprint — projecting cost-per-lead, cost-per-enrollment, and enrollment velocity with mathematical precision.

03

Optimized Execution

CT Scan executes against DYNO's forecasts — optimizing ad strategy, budget allocation, site selection, and funnel management in real time against the model.

Ryan's Mandate

Translate Predictive Enrollment Engineering™ into practical implementation across sponsors, CROs, and site networks — projecting cost-per-lead, cost-per-enrollment, and enrollment velocity ahead of activation, then operationalizing recruitment against the model.

"Enrollment should be engineered with mathematics, not hoped into existence."
Experience CT SCAN

Launch DYNO Ai™ — dyno.clinicaltrialscan.ai

§ 03 — Experience

Eighteen years inside the problem.

Feb 2026 — Present

Chief Strategy Officer

CT Scan
Remote

Advancing Predictive Enrollment Engineering™ powered by DYNO Ai™. Translating the framework into practical implementation across sponsors, CROs, and site networks.

Aug 2020 — Present · 5 yrs 11 mos

Founder & Principal Consultant

Research Minded
Orange County, CA · Remote

Advising independent sites, specialty practices, and hospital programs on startup strategy, budgeting, workflow design, and enrollment execution.

Jan 2022 — Aug 2023 · 1 yr 8 mos

Director of Clinical Research — Finance & Regulatory

Hoag Health System
Orange County, CA

Oversaw financial and regulatory infrastructure for clinical research across the hospital system — budget strategy, coverage analysis, billing compliance, and investigator payments.

Feb 2016 — Jan 2022 · 6 yrs

Administrator

Hoag Orthopedics
Orange County, CA · Hybrid

Built operational infrastructure for fellowship programs (Sports Medicine, Total Joint, Spine) and led the orthopedic clinical research program end-to-end.

Mar 2014 — Feb 2016 · 2 yrs

Clinical Research Manager

MemorialCare
Long Beach, CA

Led clinical research coordinators across multiple therapeutic areas; integrated research into routine clinical care and reduced startup delays.

Feb 2013 — Mar 2014 · 1 yr 2 mos

Clinical Project Manager II

CHI
Englewood, CO

Coordinated study startup, regulatory, and execution across a large hospital system — first deep look at how clinic capacity, not protocol, gates enrollment.

Jun 2012 — Feb 2013 · 9 mos

Project Manager

Pharmatech
Denver, CO

First role outside the site environment — bridging sponsor timelines with site operational reality.

Jun 2008 — Jun 2012 · 4 yrs 1 mo

Clinical Research Coordinator → Team Manager

University of Colorado Anschutz Cancer Center
Denver, CO

Began career in oncology trials (GI, Head & Neck, Thyroid). Patient-level work that shaped a lifelong focus on access, feasibility, and enrollment predictability.

§ 04 — Connect

If you work in clinical research,
let's exchange ideas.

Sponsor, CRO, site, or partner — Ryan is always happy to talk enrollment, feasibility, and the upstream work that makes trials succeed.

Start a conversation
CT Scan · CSO·Research Minded · Founder·Orange County, CA
© 2026 Ryan Helber
Predictive Enrollment Engineering™